Stem cell therapy - Gynecology

Thin and non-receptive endometrium

Indications to stem cell treatment:

- Thin and non-receptive endometrium

Сontraindications to treatment:

- Malignant neoplasms
- Critical disorders of blood coagulation system (platelet count ≤50×109)                                                                                      - Severe heart failure
- Severe pulmonary failure (SpO2 <90%)
- Kidney failure of IV-V degree
- Infectious diseases in the acute phase (hepatitis C, hepatitis B, etc.)
- Unstable hemodynamics, requiring correction with sympathomimetics                                                                                        - Terminal stage of incurable diseases
- Acute stage of injuries or stroke
- Pregnancy, pregnancy planning shortly, breastfeeding
- Purulent joint diseases

Therapeutic effects:

The therapeutic effect of stem cells is achieved due to their ability to differentiate and transdifferentiate into tissue-specific cells, to fuse with the resident cells, to secrete a wide array of paracrine factors to stimulate the survival and functional recovery of the resident cells, or to regulate the local microenvironment or immune response.

Using MSC, we can achieve positive effects in those clinical cases, which were non-perspective because of traditional options of therapy.

The positive effects might be expected: Cell therapy trials for the treatment of endometrial pathologies, have reported promising findings, with demonstrable safety and early proof of efficacy, temporary amelioration of the intrauterine environment, and an increase in endometrial thickness, receptivity and as a result, increase in a chance for pregnancy. After the first injection, the endometrium grows by 6.5 mm. An increase in endometrial thickness may be measured by ultrasound diagnostic.

Positive effects were reported in 76 % of cases during 6-9 months after stem cell therapy.

What does the procedure look like?

Stem cell treatment procedure is non-surgical, is practically painless, and well-tolerated by patients. Possible short-term side effects immediately after cell transplantation are redness at the injection site and a slight increase in body temperature. These effects usually subside in 1 to 2 hours. The method of administration of cellular material is chosen by the doctor individually for each case.

When will I see the results?

Patient response to treatment is dependent on a large variety of biological factors, however is also subject to the behavior and lifestyle of the patient. We advise patients that stem cell therapy normally produces measurable results within 3-6-9 months following treatment. However, we have had many patients record improvements to their quality of life and a lessening of their symptoms within the first few weeks following treatment. Every patient is unique and will respond to treatment differently so it is impossible to guarantee any specific result for an individual, as every person’s body is different and will respond in different ways.

Is it safe?

Stem cell therapy using Mesenchymal Stem Cells is absolutely safe. There are no side effects associated with stem cell therapy. In very rare cases: a slight increase in temperature after the procedure is possible; slight redness at the injection site, - all these effects pass within a few hours.

The package includes:

- 30+ medical tests
- doctor`s consultations
- Accommodation (at clinic or 3* hotel)
- Translation service (English, Chinese, Russian, Ukrainian)
- Transfer from/to airport
- 24/7 support
- Medical follow-up for 1 year

*Stem cell material up to 60 million cells, (dosage and type of stem cell material are chosen by our doctors for each patient individually).

**The list of examinations can be modified or enlarged by the doctor’s recommendations.

Possible methods of cellular material administration:

- In endometrium
- Other methods of administration

Each patient is provided with the Certificate of Analysis of stem cell material confirming its quality.

The schedule of the patient's stay (2 visits are necessary):

- During the first visit to Vitality which lasts for 3 days we will make all the necessary tests; provide consultations with the therapist and gynecologist and if everything is fine, we will carry out the patients' biomaterial sampling procedure.

Then the patient leaves us for 4-6 weeks while we’re cultivating patients' Stem Cells. In 4-6 weeks (when the Stem Cells are ready) we will invite the patient to undergo the procedure of cellular material administration.

- During the second visit which lasts for 3 days, we'll provide laboratory diagnostics (basic biochemical and general clinical indicators); doctors' consultation on the results; Stem Cells administration.

*The city tour is not included but can be organized additionally.

All-inclusive package price: 7110 EUR

Our center is a part of ADONIS Medical Group of Companies - one of the biggest private clinic networks based in Eastern Europe (Kyiv), operating for more than 20 years on the market of medical services.

Vitality medical & research center is accredited by the Ministry of Health of Ukraine and has a license for the cord blood & stem cell bank as well as its own biotechnological stem cell laboratory.

Our clinic staff is a member of the International Society for Stem Cell Research and Regenerative Medicine International Society (TERMIS).

At Vitality medical & research center we provide stem cell treatment for a wide variety of diseases following exceptional quality and safety standards that is why we use only Mesenchymal Stem Cells produced in our completely licensed and certified laboratory.

Dosage and type of stem cell material are chosen by our doctors for each patient individually. Each of our patients is provided with the Certificate of Analysis of stem cell material confirming its quality, purity, safety, and dosage. It is possible to use donors as well as the patient's own material.



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