Stem cell therapy - Gynecology (ovarian dysfunction)

Ovarian dysfunction

Indications to stem cell treatment:

- premature ovarian failure                                                                                                                                                              - amenorrhea
- hypergonadotropism
- hypoestrogenism                                                                                                                                                                          - early menopause
- prolongation of ovarian reserve                                                                                                                                                    - polycystic ovary syndrome

Сontraindications to treatment:

- Malignant neoplasms
- Critical disorders of blood coagulation system (platelet count ≤50×109)                                                                                     - Severe heart failure
- Severe pulmonary failure (SpO2 <90%)
- Kidney failure of IV-V degree
- Infectious diseases in the acute phase (hepatitis C, hepatitis B, etc.)
- Unstable hemodynamics, requiring correction with sympathomimetics                                                                                        - Terminal stage of incurable diseases
- Acute stage of injuries or stroke
- Pregnancy, pregnancy planning in the near future, breastfeeding
- Purulent joint diseases

Therapeutic effects:

Mesenchymal stem cell treatment improves hormone production, ovarian size, endometrial thickness, and endometrial blood flow.

Stem cell treatment restores ovarian function and leads to the production of immature oocytes. In women, ultrasounds demonstrated that mesenchymal stem cell treatment improved both ovarian size and endometrial thickness of patients with premature ovarian failure. Moreover, blood flow analysis demonstrated a richer signal in the endometrium. In a recent study stem cell treatment of premature ovarian failure resumed menstruations and allowed a woman to get pregnant and to give birth to a full-term healthy baby.

Menstruations restarted 3 months after stem cell therapy in 20% of treated women after the first stem cell administration, which regained ovarian reserve and the secretory function of a previously atrophic endometrium.

Monitoring the worlds most reliable resources - PubMed, Cochrane, Embase,
Scopus, and ProQuest shows 648 published studies on stem cell-based therapy
for the treatment of various types of ovarian insufficiency and disorders, shows that stem cells could accelerate ovarian tissues rejuvenation, regulate systemic sex-related hormone levels and eventually increase fertility rate. The evidence suggests that stem cell-based therapies could be considered as an alternative modality to deal with women undergoing POI.

What does the procedure look like?

Stem cell treatment procedure is non-surgical, is practically painless, and well-tolerated by patients. Possible short-term side effects immediately after cell transplantation are redness at the injection site and a slight increase in body temperature. These effects usually subside in 1 to 2 hours. The method of administration of cellular material is chosen by the doctor individually for each case.

When will I see the results?

Patient response to treatment is dependent on a large variety of biological factors, however is also subject to the behavior and lifestyle of the patient. We advise patients that stem cell therapy normally produces measurable results within 3-6-9 months following treatment. However, we have had many patients record improvements to their quality of life and a lessening of their symptoms within the first few weeks following treatment. Every patient is unique and will respond to treatment differently so it is impossible to guarantee any specific result for an individual, as every person’s body is different and will respond in different ways.

Is it safe?

Stem cell therapy using Mesenchymal Stem Cells is absolutely safe. There are no side effects associated with stem cell therapy. In very rare cases: a slight increase in temperature after the procedure is possible; slight redness at the injection site, - all these effects pass within a few hours.

The package includes:

- 30+ medical tests
- doctor`s consultations
- Accommodation (at clinic or 3* hotel)
- Translation service (English, Chinese, Russian, Ukrainian)
- Transfer from/to airport
- 24/7 support
- Medical follow-up for 1 year

*Stem cell material up to 30 million cells; umbilical cord, menstrual blood, or adipose-derived stem cells may be used (dosage and type of stem cell material are chosen by our doctors for each patient individually).

**The list of examinations can be modified or enlarged in accordance with the doctor’s recommendations.

Possible methods of cellular material administration:

- intravenously

- intraovarian

Each patient is provided with the Certificate of Analysis of stem cell material confirming its quality.

All-inclusive package price: 7110 EUR

*In case of using your own stem cell material, 2 visits are needed. Package price rises by 25%

The schedule of the patient's stay :

Day 1 - arrival;
Day 2- passing medical tests;
Day 3- consultation with a specialized doctor, analysis of test results;
Day 4 - consultation with therapist and stem cells injections;
Day 5 - free day at the clinic, patient observation, departure;

*The city tour is not included but can be organized additionally.

Our center is a part of ADONIS Medical Group of Companies - one of the biggest private clinic networks based in Eastern Europe (Kyiv), operating for more than 20 years on the market of medical services.

Vitality medical & research center is accredited by the Ministry of Health of Ukraine and has a license for the cord blood & stem cell bank as well as its own biotechnological stem cell laboratory.

Our clinic staff are members of the International Society for Stem Cell Research and Regenerative Medicine International Society (TERMIS).

At Vitality medical & research center we provide stem cell treatment for a wide variety of diseases following exceptional quality and safety standards that is why we use only Mesenchymal Stem Cells produced in our completely licensed and certified laboratory.

Dosage and type of stem cell material are chosen by our doctors for each patient individually. Each of our patients is provided with the Certificate of Analysis of stem cell material confirming its quality, purity, safety, and dosage. It is possible to use donors as well as the patient's own material.


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